Synthesis and antimicrobial activities of novel quinoline derivatives carrying 1,2,4-triazole moiety.

@article{Eswaran2009SynthesisAA,
  title={Synthesis and antimicrobial activities of novel quinoline derivatives carrying 1,2,4-triazole moiety.},
  author={Sumesh Eswaran and Airody Vasudeva Adhikari and Nitinkumar S. Shetty},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 11},
  pages={4637-47}
}
A new class of quinoline derivatives containing 1,2,4-triazole moiety were synthesized from derivatives of 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbohydrazide 4 through multi-step reactions. The compound 4, on treatment with substituted Isothiocyanates yielded quinoline-thiosemicarbazides 5a-c, which were conveniently cyclized to (5-mercapto-4H-triazol-3-yl)-quinolin-4-ols 6a-c in basic medium. These intermediates were then transformed to their respective chloro derivatives 7a-c by… CONTINUE READING