Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines.

@article{Lu2013SynthesisAA,
  title={Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines.},
  author={Wen-Jie Lu and Kathryn Jean Wicht and Li Wang and Kento Imai and Zhen-Wu Mei and M Kaiser and Ibrahim El Tantawy El Sayed and Timothy J Egan and Tsutomu Inokuchi},
  journal={European journal of medicinal chemistry},
  year={2013},
  volume={64},
  pages={498-511}
}
This report describes the synthesis, and in vitro and in vivo antimalarial evaluations of certain ester-modified neocryptolepine (5-methyl-5H-indolo[2,3-b]quinoline) derivatives. The modifications were carried out by introducing ester groups at the C2 and/or C9 position on the neocryptolepine core and the terminal amino group of the 3-aminopropylamine substituents at the C11 position with a urea/thiourea unit. The antiplasmodial activities of our derivative agents against two different strains… CONTINUE READING