Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.

@article{Iwaniuk2009SynthesisAA,
  title={Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.},
  author={Daniel P Iwaniuk and Eric D Whetmore and Nicholas Rosa and Kekeli A Ekoue-Kovi and John N Alumasa and Angel C de Dios and Paul D Roepe and Christian Wolf},
  journal={Bioorganic & medicinal chemistry},
  year={2009},
  volume={17 18},
  pages={6560-6}
}
We report the synthesis and in vitro antimalarial activity of several new 4-amino- and 4-alkoxy-7-chloroquinolines carrying a linear dibasic side chain. Many of these chloroquine analogues have submicromolar antimalarial activity versus HB3 (chloroquine sensitive) and Dd2 (chloroquine resistant strain of Plasmodium falciparum) and low resistance indices… CONTINUE READING