Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives.

@article{Zarranz2005SynthesisAA,
  title={Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives.},
  author={B. Zarranz and A. Jaso and I. Aldana and A. Monge and S. Maurel and E. Deharo and V. Jullian and M. Sauvain},
  journal={Arzneimittel-Forschung},
  year={2005},
  volume={55 12},
  pages={
          754-61
        }
}
New series of 3-arylquinoxaline-carbonitrile derivatives have been synthesized from various 5-substituted or 5,6-disubstituted benzofuroxanes and tested for their in vitro and in vivo activity against the erythrocytic development of Plasmodium falciparum strain with different chloroquine-resistance status. Quinoxaline 1,4-dioxide derivatives showed superior antimalarial activity in respect to reduced quinoxaline analogues. The best activity was observed with nonsubstituted quinoxaline 1,4… Expand
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