Synthesis and antileishmanial activity of novel 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines.

@article{Sunduru2009SynthesisAA,
  title={Synthesis and antileishmanial activity of novel 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines.},
  author={Naresh Sunduru and Nishi and Shraddha Palne and Prem Man Singh Chauhan and Suman Gupta},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 6},
  pages={2473-81}
}
A series of 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines have been synthesized and screened for their in vitro and in vivo antileishmanial activity against Leishmania donovani. Among all, 14 compounds have shown promising inhibition of 80-100% at 10 microg/ml against promastigotes and IC(50) in the range of 0.89-9.68 microg/ml against amastigotes… CONTINUE READING