Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues.

Abstract

A series of novel hexahydrothiopyrano[4,3-c]pyrazoles and related analogues were prepared and tested for antiinflammatory activity by using the mouse active Arthus reaction and the delayed hypersensitivity skin reaction in guinea pigs as primary screens. The compounds of most interest, 18 and 28, were further tested in a model of adjuvant-induced arthritis… (More)

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Cite this paper

@article{Rovnyak1982SynthesisAA, title={Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues.}, author={George Rovnyak and Renate Millonig and J. Schwartz and Vincent S Shu}, journal={Journal of medicinal chemistry}, year={1982}, volume={25 12}, pages={1482-8} }