Synthesis and antiinflammatory activity of coumarin derivatives.

  title={Synthesis and antiinflammatory activity of coumarin derivatives.},
  author={Christos A Kontogiorgis and Dimitra Hadjipavlou-Litina},
  journal={Journal of medicinal chemistry},
  volume={48 20},
The synthesis of several coumarin Mannich bases is described. The structures of the synthesized compounds were confirmed by spectral and elemental analysis. Their lipophilicity was determined experimentally by RPTLC method. All compounds were evaluated for their antiinflammatory and antioxidant activity and for their ability to inhibit in vitro lipoxygenase. The derivatives were found to present antioxidant and antiinflammatory activities. The tested derivatives inhibited carraggeenin-induced… CONTINUE READING