Synthesis and antifungal properties of papulacandin derivatives

@article{Kaaden2012SynthesisAA,
  title={Synthesis and antifungal properties of papulacandin derivatives},
  author={M. van der Kaaden and E. Breukink and R. Pieters},
  journal={Beilstein Journal of Organic Chemistry},
  year={2012},
  volume={8},
  pages={732 - 737}
}
  • M. van der Kaaden, E. Breukink, R. Pieters
  • Published 2012
  • Chemistry, Medicine
  • Beilstein Journal of Organic Chemistry
    • Summary Derivatives of an antifungal agent that targets the β-(1,3)-D-glucan synthase, papulacandin D, were synthesized and tested for activity. The papulacandin D structure contains a challenging benzannulated spiroketal unit, which is introduced in a palladium-catalyzed cross-coupling reaction of a glycal silanolate and an aryl iodide followed by an oxidative spiroketalization. Four different variants were made, differing in the nature of the acyl side chain with respect to the length, and in… CONTINUE READING
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