Synthesis and anticonvulsant activity of 3-(3'-trifluoromethylphenoxy)-pyridines and -dihydropyridines.

Abstract

3-(3"Trifluoromethylphenoxy)-1,4-dihydropyridines containing phenoxycarbonyl, methoxycarbonyl or acetyl at the 1 position, and phenyl, n-butyl or methyl at the 4-position were synthesised (generalised structure 4). Four members of this series (4a-c, 4g)--the rest were not evaluated because of their facile oxidation to pyridines--were found to be inactive in… (More)

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