Synthesis and anticancer activity of new thiazolo[3,2-a]pyrimidines: DNA binding and molecular modeling study.

Abstract

A novel series of nitrogenous heterocycles starting from chalcones including thiazolo[3,2-a]pyrimidines (20-67), were synthesized. Structure elucidation of the synthesized compounds was attained by the use of 1H NMR, 13CC NMR, and Mass spectrometry. The obtained compounds were evaluated for their in vitro anticancer activity at the National Cancer Institute… (More)
DOI: 10.1016/j.bioorg.2017.07.008

Topics

Cite this paper

@article{Hassan2017SynthesisAA, title={Synthesis and anticancer activity of new thiazolo[3,2-a]pyrimidines: DNA binding and molecular modeling study.}, author={Ghada S. Hassan and Shahenda M. El-Messery and Ahmad Abbas}, journal={Bioorganic chemistry}, year={2017}, volume={74}, pages={41-52} }