Synthesis and anticancer activity of new quinazoline derivatives.

  title={Synthesis and anticancer activity of new quinazoline derivatives.},
  author={Hatem A Abuelizz and Mohamed Marzouk and Hazem A Ghabbour and Rashad A Al-Salahi},
  journal={Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society},
  volume={25 7},
In this study, a new series of quinazoline derivatives (3-26) was synthesized and characterized via physicochemical and spectral means. Treatment of 2-amino-5-methylbenzoic acid with butyl isothiocyanate resulted in the new 2-thioxoquinazolin-4-one (3). Alkylation and hydrazinolysis of the inherent thioxo group in (1-3) afforded the corresponding thioethers… CONTINUE READING