Synthesis and anticancer activity of glucosylated podophyllotoxin derivatives linked via 4β-triazole rings.

Abstract

A series of 4β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using MTT assays. Most of these triazole derivatives have good… (More)
DOI: 10.3390/molecules181113992

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