Design of New 2,4-Substituted Furo [3,2-B] Indole Derivatives as Anticancer Compounds Using Quantitative Structure-Activity Relationship (QSAR) and Molecular Docking
- Chemistry, Biology
The QSAR analysis showed that compound 15 has the best predicted anticancer activity, supported by molecular docking results that showed hydrogen bond interaction with essential amino acids to build anticancers activity such as MET769, THR830, and THR766 residues.
Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells.
- Chemistry, BiologyEuropean journal of medicinal chemistry
To Create Your Abstract, Type Over the Instructions in the Template Box Below.Diastereoselective Construction of Novel Penta Cyclic Indolo-Furo[3,2-C]Quinoline and Dihydrochromeno-Furo[2,3-B]Indol Via Sequential Annulation Strategy
- ChemistrySSRN Electronic Journal
TFA-catalyzed Q-Tube Reactor-Assisted Strategy for the Synthesis of Pyrido[1,2-b][1,2,4]triazine and Pyrido[1′,2′:2,3][1,2,4]triazino[5,6-b]indole Derivatives
- ChemistryACS omega
X-ray single-crystal analysis was utilized in this study to authenticate the structure of the synthesized products and was found to be superb in comparison to that under the traditional refluxing conditions.
Fe3O4 magnetic nanoparticles (MNPs) as an effective catalyst for synthesis of indole derivatives
The principal aim of this research is the application of Fe3O4 (MNPs) in the synthesis of some indole derivatives. Fe3O4 MNPs were prepared by Co-Precipitation method from the reaction of FeCl2.4H2O…
Synthesis and SAR studies of novel 6,7,8‐substituted 4‐substituted benzyloxyquinolin‐2(1H)‐one derivatives for anticancer activity
- ChemistryBritish journal of pharmacology
Four new 4‐Phenylquinolin‐2(1H)‐one derivatives can induce cancer cell apoptosis and were investigated as more effective, less toxic antitumour agents.
SYNTHESIS AND CYTOTOXIC STUDIES OF 2, 3-DIMETHYLINDOLES AND TETRAHYDROCARBAZOLES
Objective: The objective of this study was to report the synthesis of 2,3-dimethylindoles and tetrahydrocarbazoles via Fisher indole synthesis and evaluation of their the anticancer properties.…