Synthesis and antibacterial and analgesic activity of 5-aryl-4-acyl-3-hydroxy-1(2,2-dimethoxyethyl)-3-pyrrolin-2-ones

@article{Gein2010SynthesisAA,
  title={Synthesis and antibacterial and analgesic activity of 5-aryl-4-acyl-3-hydroxy-1(2,2-dimethoxyethyl)-3-pyrrolin-2-ones},
  author={Vladimir L. Gein and V. N. Vychegzhanina and Elena B. Levandovskaya and Boris Ya. Syropyatov and Mikhail I Vakhrin and Elena V. Voronina and Natalya Danilova},
  journal={Pharmaceutical Chemistry Journal},
  year={2010},
  volume={44},
  pages={370-373}
}
5-Aryl-4-acyl-3-hydroxy-1-(2,2-dimethoxyethyl)-3-pyrrolin-2-ones were synthesized by the reaction of acylpyruvic acid methyl esters with a mixture of an aromatic aldehyde and aminoacetaldehyde dimethylacetal. The proposed structures are confirmed by IR and PMR spectroscopy. The results of an investigation of the antibacterial and analgesic activity of the synthesized compounds are presented. 

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Tetrahydropyrrol- and Tetrahydrofuran-2,3-diones [in Russian

  • V. L. Gein
  • 2004

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