Synthesis and antibacterial activity of betulonic acid amides with piperazine derivatives

@article{Chue2011SynthesisAA,
  title={Synthesis and antibacterial activity of betulonic acid amides with piperazine derivatives},
  author={K Lee Chue and M.-S. Chang and Leonid N. Ten},
  journal={Chemistry of Natural Compounds},
  year={2011},
  volume={47},
  pages={759-763}
}
New betulonic acid amides with piperazine derivatives were synthesized by the acid-chloride method and characterized using spectral data. It was shown that synthesized compounds 2–7 exhibited varied antibacterial activity. The most active of them was betulonic acid amide of 1-(3,4-dichlorophenyl)piperazine (3) and 1-(4-trifluoromethylphenyl)piperazine (7).