Synthesis and antibacterial activity of alaremycin derivatives for the porphobilinogen synthase.

Abstract

The preparation and the antibacterial activity of alaremycin derivatives such as their CF(3)-derivatives and (R)- and (S)-4-oxo-5-acetylaminohexanoic acid for the porphobilinogen synthase (PBGS), were described. The IC(50) values of the antibacterial activity of the prepared materials for the inhibitor of PBGS, were determined using PBGS assay.

DOI: 10.1016/j.bmcl.2011.03.106

Cite this paper

@article{Iwai2011SynthesisAA, title={Synthesis and antibacterial activity of alaremycin derivatives for the porphobilinogen synthase.}, author={Noritaka Iwai and Kyosuke Nakayama and Jumpei Oku and Tomoya Kitazume}, journal={Bioorganic & medicinal chemistry letters}, year={2011}, volume={21 10}, pages={2812-5} }