Synthesis and anti-inflammatory evaluations of β-lapachone derivatives.

  title={Synthesis and anti-inflammatory evaluations of β-lapachone derivatives.},
  author={C R Tseng and Chih Mei Cheng and Cherng-Chyi Tzeng and Shin-I Peng and C Yang and Yeh-long Chen},
  journal={Bioorganic & medicinal chemistry},
  volume={21 2},
β-Lapachone (β-LAPA), a natural product from the lapacho tree in South America, is a potential chemotherapeutic agent that exhibit a wide variety of pharmacological effects such as anti-virus, anti-parasitic, anti-cancer, and anti-inflammatory activities. In order to discover novel anti-inflammatory agents, we have synthesized a series of β-LAPA derivatives for evaluation. Among them, 4-(4-methoxyphenoxy)naphthalene-1,2-dione (6b) was found to be able to inhibit NO and TNF-α released in LPS… CONTINUE READING