Synthesis and anti-angiogenic activity of cortistatin analogs.

  title={Synthesis and anti-angiogenic activity of cortistatin analogs.},
  author={Yuuki Sato and Hiroshi Kamiyama and Takeo Usui and Tamio Saito and Hiroyuki Osada and Shigefumi Kuwahara and Hiromasa Kiyota},
  journal={Bioscience, biotechnology, and biochemistry},
  volume={72 11},
Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of… CONTINUE READING