Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir.

@article{Rouquayrol2001SynthesisAA,
  title={Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir.},
  author={M. Rouquayrol and B. Gaucher and J. Greiner and A. Aubertin and P. Vierling and R. Guedj},
  journal={Carbohydrate research},
  year={2001},
  volume={336 3},
  pages={
          161-80
        }
}
With the aim at improving the transport of the current HIV protease inhibitors across the intestinal and blood brain barriers and their penetration into the central nervous system, the synthesis of various acyl and carbamatoyl glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir, their in vitro stability with respect to hydrolysis, and their anti-HIV activity have been investigated. D-Glucose, which is actively transported across these barriers, was connected through… Expand
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