Synthesis and anti-HIV activity of guanidinoglycosides.

  title={Synthesis and anti-HIV activity of guanidinoglycosides.},
  author={TransportA. J. Baker and Nathan W Luedtke and Yitzhak Tor and Murray J Goodman},
  journal={The Journal of organic chemistry},
  volume={65 26},
The new guanidinylation reagent N,N'-diBoc-N''-triflylguanidine was used to efficiently convert multiamine-containing glycosides including kanamycin A and B, tobramycin, paromomycin, and neomycin B to the corresponding fully guanidinylated analogues (guanidinoglycosides). This transformation occurs in the presence of H(2)O under mild conditions… CONTINUE READING