Synthesis and anti-HIV-1 activity of 4-substituted-7-(2'-deoxy-2'-fluoro-4'-azido-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine analogues.

@article{Guo2011SynthesisAA,
  title={Synthesis and anti-HIV-1 activity of 4-substituted-7-(2'-deoxy-2'-fluoro-4'-azido-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine analogues.},
  author={Xiaohe Guo and Yujiang Li and Le Quang Tao and Qiang Wang and Shuyang Wang and Weidong Hu and Zhenliang Pan and Qinghua Yang and Yanmei Cui and Zhaopeng Ge and Lihong Dong and Xuejun Yu and Haoyun An and Chuanjun Song and Junbiao Chang},
  journal={Bioorganic & medicinal chemistry letters},
  year={2011},
  volume={21 22},
  pages={
          6770-2
        }
}
Three novel 4-subsituted-7-(2'-deoxy-2'-fluoro-4'-azido-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine analogues were designed, synthesized, and tested for their anti-HIV-1 activity. Initial biological studies indicated that among these pyrrolo[2,3-d]pyrimidine ribonucleoside analogues, 4-amino-7-(2'-deoxy-2'-fluoro-4'-azido-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 10 exhibited the most potent anti-HIV-1 activity (EC(50)=0.5±0.3 μM), while 4-hydroxy-7-(2'-deoxy-2'-fluoro-4'-azido-β-D… CONTINUE READING
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