Synthesis and analgesic effect of normorphine-3- and -6-glucuronides.

@article{Oguri1989SynthesisAA,
  title={Synthesis and analgesic effect of normorphine-3- and -6-glucuronides.},
  author={Kazuta Oguri and C K Kuo and Hidetoshi Yoshimura},
  journal={Chemical & pharmaceutical bulletin},
  year={1989},
  volume={37 4},
  pages={955-7}
}
Normorphine-3- and -6-glucuronides were synthesized, and their analgesic effects were examined. Normorphine-3-glucuronide was obtained by condensation of normorphine with acetobromoglucuronate in the presence of sodium hydroxide in acetone. On the other hand, normorphine-6-glucuronide was synthesized by condensing N,O3-biscarbobenzoxynormorphine with acetobromoglucuronate in the presence of silver carbonate, and removing the protecting groups from the resultant reaction product by catalytic… CONTINUE READING