Synthesis and activity of substituted carbamates as potentiators of the alpha4beta2 nicotinic acetylcholine receptor.

Abstract

The synthesis and structure-activity relationship of a series of carbamate potentiators of alpha4beta2 nAChR is reported herein. These compounds were highly selective for alpha4beta2 over other nAChR subtypes. In addition, compounds increased the response of alpha4beta2 nAChRs to acetylcholine, as measured with patch-clamp electrophysiology.

DOI: 10.1016/j.bmcl.2008.08.092

Statistics

05010020102011201220132014201520162017
Citations per Year

61 Citations

Semantic Scholar estimates that this publication has 61 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Springer2008SynthesisAA, title={Synthesis and activity of substituted carbamates as potentiators of the alpha4beta2 nicotinic acetylcholine receptor.}, author={Stephanie K Springer and Katrina S Woodin and Virginia Berry and Alessandro A. Boezio and Lei Cao and Kristie C. Clarkin and Jean-Christophe P Harmange and Markus Hierl and Johannes Knop and Annika B . Malmberg and Jeff McDermott and Hung Quoc Nguyen and Daniel J. Waldon and Brian Albrecht and Stefan I. McDonough}, journal={Bioorganic & medicinal chemistry letters}, year={2008}, volume={18 20}, pages={5643-7} }