• DOI:10.1039/c5ob02482j
Corpus ID: 5669797

Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI: 10.1039/c5ob02482j Click here for additional data file.

@article{Gotham2016SynthesisAA,
  title={Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI: 10.1039/c5ob02482j Click here for additional data file.},
  author={Victoria J. B. Gotham and Melanie C. Hobbs and Ryan N Burgin and D. Turton and C. Smythe and I. Coldham},
  journal={Organic & Biomolecular Chemistry},
  year={2016},
  volume={14},
  pages={1559 - 1563}
}

Victoria J. B. Gotham, Melanie C. Hobbs, +3 authors I. Coldham

Published 2016

Chemistry, Medicine

Organic & Biomolecular Chemistry

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A new route to a tetracyclic lactam was developed and the product, called VG1, was found to inhibit nonsense-mediated mRNA decay at μM concentrations.