Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.

Abstract

Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.

Cite this paper

@article{Barbey2002SynthesisAA, title={Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.}, author={Sabine Barbey and Laurence Goossens and Thierry Taverne and Jos{\'e}phine Cornet and Val{\'e}rie Choesmel and C{\'e}line Rouaud and Gilles Gimeno and Sylvie Yannic-Arnoult and Catherine Michaux and Caroline Charlier and Raymond Houssin and Jean Pierre H{\'e}nichart}, journal={Bioorganic & medicinal chemistry letters}, year={2002}, volume={12 5}, pages={779-82} }