Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.

@article{Zhao2005SynthesisAA,
  title={Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.},
  author={Chen Zhao and Hing Leung Sham and Minghua Sun and Vincent S. Stoll and Kent D. Stewart and Shuqun Lin and Hongmei Mo and Sudthida Vasavanonda and Ayda Saldivar and Chang Hee Park and Edith J McDonald and Kennan C. Marsh and Larry L. Klein and Dale J. Kempf and Daniel W. Norbeck},
  journal={Bioorganic & medicinal chemistry letters},
  year={2005},
  volume={15 24},
  pages={5499-503}
}
As part of our efforts to identify potent HIV-1 protease inhibitors that are active against resistant viral strains, structural modification of the azacyclic urea (I) was undertaken by incorporating acyl groups as P(1)' ligands. The extensive SAR study has yielded a series of N-acyl azacyclic ureas (II), which are highly potent against both wild-type and… CONTINUE READING