Synthesis and Structure Revision of Dichrocephones A and B.

@article{Schmiedel2018SynthesisAS,
  title={Synthesis and Structure Revision of Dichrocephones A and B.},
  author={Volker M Schmiedel and Young Joo Hong and Dieter Lentz and Dean J. Tantillo and Mathias Christmann},
  journal={Angewandte Chemie},
  year={2018},
  volume={57 9},
  pages={
          2419-2422
        }
}
Herein, we report the first enantioselective synthesis of dichrocephones A and B, which are cytotoxic triquinane sesquiterpenes with a dense array of stereogenic centers within a strained polycyclic environment. Key features include the application of a catalytic asymmetric Wittig reaction, followed by stereoselective functionalization of the propellane core into a pentacyclic intermediate. Double reductive ring cleavage yielded the proposed structure of dichrocephone A. Mismatched… CONTINUE READING
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