Synthesis and Structure Revision of Dichrocephones A and B.

  title={Synthesis and Structure Revision of Dichrocephones A and B.},
  author={Volker M Schmiedel and Young Joo Hong and Dieter Lentz and Dean J. Tantillo and Mathias Christmann},
  journal={Angewandte Chemie},
  volume={57 9},
Herein, we report the first enantioselective synthesis of dichrocephones A and B, which are cytotoxic triquinane sesquiterpenes with a dense array of stereogenic centers within a strained polycyclic environment. Key features include the application of a catalytic asymmetric Wittig reaction, followed by stereoselective functionalization of the propellane core into a pentacyclic intermediate. Double reductive ring cleavage yielded the proposed structure of dichrocephone A. Mismatched… CONTINUE READING
This paper has been referenced on Twitter 11 times. VIEW TWEETS

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…