Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia.


We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure-activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia. 
DOI: 10.1021/acsmedchemlett.7b00479


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics