Synthesis and Separation of Dinucleoside Phenylphosphonate Diastereomers

@article{Hashmi1994SynthesisAS,
  title={Synthesis and Separation of Dinucleoside Phenylphosphonate Diastereomers},
  author={S. A. Nadeem Hashmi and Anil Kumar and S. B. Kacti},
  journal={Nucleosides, Nucleotides \& Nucleic Acids},
  year={1994},
  volume={13},
  pages={1039-1047}
}
Abstract Dinucleoside phenylphosphonates have been synthesized in excellent yields using 6-Nitrobenzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (NBOP) as a coupling reagent. A general method for the resolution of two diastereomers of phenylphosphonate dimers has been developed. 
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4 Citations

4 Citations

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The stereodependent transport of a P-stereoregular oligonucleotide through a model organic liquid membrane is described, extending the knowledge of the physicochemical properties of single-stranded methylphosphonate olig onucleotides in solution, and might facilitate cellular uptake of future antisense oligon nucleotide drugs.
Structure and Physical–Chemical Properties of Nitroazoles
The critical evaluation of a large body of the information on five-membered nitroazoles and nitrobenzazoles study by physical chemical methods – nuclear magnetic resonance (NMR), nuclear quadrupole…
Synthesis and Separation of Dinucleoside Phenylphosphonate Diastereomers.

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