Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents.

@article{Wang2012SynthesisAS,
  title={Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents.},
  author={Ziwen Wang and Meng Wu and Yi Wang and Zheng Li and Lei Wang and Guifang Han and Fazhong Chen and Yuxiu Liu and Kailiang Wang and Ao Zhang and Linghua Meng and Qingmin Wang},
  journal={European journal of medicinal chemistry},
  year={2012},
  volume={51},
  pages={
          250-8
        }
}
6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
TLDR
A mechanistic evaluation showed that 2-R potently inhibited cell growth and colony formation, which is associated with a delay in S phase progression through the inhibition of DNA synthesis, which will facilitate the discovery of new Phenanthroindolizidine and phenanthroquinolIZidine alkaloids for use as anticancer drug candidates.
First Discovery and Stucture-Activity Relationship Study of Phenanthroquinolizidines as Novel Antiviral Agents against Tobacco Mosaic Virus (TMV)
TLDR
Fundamental support for development and optimization of phenanthroquinolizidine alkaloids as potential inhibitors of plant virus is provided.
Different salt derivatives of phenanthroindolizidine alkaloids display different in vitro antitumor activity
Salification is most commonly employed for modifying physical and chemical properties. However, there are few reports on the differences in biological activity between different salt forms and free
Synthesis and Antitumor Activity Evaluation of New Phenanthrene-Based Tylophorine Derivatives
TLDR
A series of new phenanthrene-based tylophorine derivatives (PBTs) were synthesized in good yield and their structures were characterized by 1H-NMR spectroscopy and ESI MS, and the structure-activity relationship of these compounds was discussed based on the results of their antitumor activity.
Phenanthrotriazine Derivatives Containing Arylidine Hydrazone Moieties as Novel Potential c-Met Inhibitors with Anticancer Effect
TLDR
Phenanthrene 1,2,4-triazines, especially the ones with less influence on normal cells, may constitute promising compounds for the discovery of antiproliferative agents with potential c-Met inhibitory capacity.
In vitro anticancer effects of two novel phenanthroindolizidine alkaloid compounds on human colon and liver cancer cells
TLDR
Chemical structure modifications of natural PAs based on anticancer activity assessments may be feasible in the development of new cancer chemotherapeutic agents.
Screening of Phenanthroquinolizidine Alkaloid Derivatives for Inducing Cell Death of L1210 Leukemia Cells with Negative and Positive P-glycoprotein Expression
TLDR
The screening of a set of cryptopleurine derivatives and (epi-)benzo analogs with bioactive phenanthroquinolizidine alkaloids that induce cytotoxic effects in the mouse lymphocytic leukemia cell line L1210 revealed that the most effective derivative 11 effectively induced cell death in S, R and T cells at similar inhibitory concentrations independent of P-gp expression.
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TLDR
This review will highlight important contributions to the isolation, synthesis, SAR and mechanism of action of the phenanthroindolizidine and pheanthroquinolIZidine alkaloids.
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