Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.

@article{Merriman2005SynthesisAS,
  title={Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.},
  author={Gregory H Merriman and Liang Ma and Patrick Joi-Tsang Shum and Daniel McGarry and Frank Volz and Jeffrey S Sabol and Alexandre Gross and Zhicheng Zhao and David Rampe and Lin Wang and Friederike Wirtz-Brugger and Bruce A Harris and Douglas Macdonald},
  journal={Bioorganic & medicinal chemistry letters},
  year={2005},
  volume={15 2},
  pages={435-8}
}
A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X(7) antagonists and their SAR is described. 

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