Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.

@article{Song2011SynthesisAS,
  title={Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.},
  author={Xinyi Song and Weimin Chen and Li Lin and Claudia H. Ruiz and Michael D. Cameron and Derek R. Duckett and Theodore M Kamenecka},
  journal={Bioorganic & medicinal chemistry letters},
  year={2011},
  volume={21 23},
  pages={
          7072-5
        }
}
The design and synthesis of a novel series of c-jun N-terminal kinase (JNK3) inhibitors is described. The development and optimization of the 2-phenoxypyridine series was carried out from an earlier pyrimidine series of JNK1 inhibitors. Through the optimization of the scaffold 2, several potent compounds with good in vivo profiles were discovered. 

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