Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds

@article{GRima1998SynthesisAR,
  title={Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds},
  author={G. Rima and J. Satg{\'e} and R. Dagiral and C. Lion and M. Fat{\^o}me and V. Roman and J. Laval},
  journal={Metal-Based Drugs},
  year={1998},
  volume={5},
  pages={139 - 146}
}
Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the… Expand
7 Citations
Synthesis and radioprotective study of new siladithioacetals and germadithioacetals
A series of organosilicon and organogermanium compounds derived from cysteamine, methylcysteamine and 2-[1-(1-naphthyl)ethyl]-2-imidazoline have been prepared and their radiopharmacologicalExpand
Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N-substituted Naphthylethylimidazoline
TLDR
The synthesis and the evaluation of the pharmacological activity of new organosilicon and organogermanium compounds such as sila- and germadithioacetals derived from N-substituted naphthylimidazolne are reported. Expand
Radioprotective activity of metalladithioacetals derived from N-substituted naphthylethylimidazoline
A number of organosilicon and organogermanium derivatives of N-substituted 2-[1-(1-naphthyl)ethyl]-2-imidazoline have been reported and the toxicity of these compounds has been determined in mice. InExpand
Synthesis and application of new organometallic compounds of silicon and germanium in chemical radioprotection
Several organosilicon and organogermanium compounds possessing radioprotective activity have been synthesized. In this paper, we describe the preparation and study of the pharmacological propertiesExpand
Synthesis and Radioprotective Effects of New Phosphorothioates Derived From Naphthylmethylimidazoline and Naphthylethylimidazoline
A number of 2-(1-naphthylmethyl)-2-imidazoline, 2-[1-(1-naphthylethyl]-2-imidazoline, phosphorothioates, and related compounds were prepared for an evaluation as radioprotective agents againstExpand
Biological Activity of Organogermanium Compounds
1 Introduction 2 Toxicity 3 Neurotropic Activity 4 Cardiovascular Activity 5 Antitumor, Antiviral and Immunomodulating Activity 6 Radioprotective Activity 7 MiscellaneousExpand
Nouveaux phosphorothioates dérivés de la naphthylméthylimidazoline et de la naphthyléthylimidazoline : application en radioprotection chimique
Dans ce travail, nous avons synthetise des phosphorothioates derives de la 2‑(1‑naphthylmethyl)-2-imidazoline et de la 2-[1-(1-naphthyl)ethyl]-2-imidazoline afin d’evaluer, in vivo chez la souris,Expand

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