Synthesis and QSAR modeling of 2-acetyl-2-ethoxycarbonyl-1-[4(4'-arylazo)-phenyl]-N,N-dimethylaminophenyl aziridines as potential antibacterial agents.

@article{Sharma2009SynthesisAQ,
  title={Synthesis and QSAR modeling of 2-acetyl-2-ethoxycarbonyl-1-[4(4'-arylazo)-phenyl]-N,N-dimethylaminophenyl aziridines as potential antibacterial agents.},
  author={Pratibha Sharma and Ashok Kumar and Siya Upadhyay and Vinita Sahu and Jitendra Kumar Singh},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 1},
  pages={251-9}
}
The present communication deals with the synthesis of a series of 2-acetyl-2-ethoxycarbonyl-1-[4(4'-arylazo)-phenyl]-N,N-dimethylaminophenyl aziridines. The compounds were synthesized in excellent yields (70-80%) and the structures were established on the basis of consistent IR, (1)H NMR and elemental analysis data. The purity has been ascertained by chromatographic resolution using acetic acid--toluene (6:4v/v) as binary eluent. All the compounds have been tested for their antimicrobial… CONTINUE READING

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