Synthesis and Properties of DNA Ligands of a New Type: Combilexein and Amyxin-Based Bisinterlexeins

Combilexeins are high-affinity DNA ligands with a structure comprising both recognition (lexitropsin) and functional (intercalator, alkylating fragment, etc.) groups. These molecules have drawn the attention of researchers due to a unique combination of properties, whereby highly specific binding of lexitropsin is retained together with a high biological… CONTINUE READING