Corpus ID: 106022335

Synthesis and Preparation of synthetic intermediates iopamidol

  title={Synthesis and Preparation of synthetic intermediates iopamidol},
  author={胡志奇 and 邢宏灯 and 吴应刚 and 李磊 and 陈满},
  • 胡志奇, 邢宏灯, +2 authors 陈满
  • Published 2012
  • Chemistry
  • From 5-amino -N, N'- bis [2-hydroxy-1- (hydroxymethyl) ethyl] -2,4,6-triiodo-1,3-benzenedicarboxamide (II) prepared starting formula (I) is (S) -N, N'- bis [2-hydroxy-1- (hydroxymethyl) ethyl] -5 - [(2-hydroxy-1-oxopropyl) amino] -2, 4,6-triiodo-1,3-benzenedicarboxamide (iopamidol) method, the method comprising a) formula (II) compound with a suitable protecting agent "mixed acid anhydride" to give the formula (III) i.e. compounds "mixed ester"; B) by (acetyloxy) propionyl chloride to the… CONTINUE READING

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