Synthesis and Preliminary Pharmacological Study of Thiophene Analogues of the Antipyretic and Analgesic Agent Ethenzamide

@article{Darias1992SynthesisAP,
  title={Synthesis and Preliminary Pharmacological Study of Thiophene Analogues of the Antipyretic and Analgesic Agent Ethenzamide},
  author={V. Darias and L. Bravo and S. Abdallah and C. Mateo and M. A. Exp{\'o}sito‐orta and J. Lissavetsky and J. Manzanares},
  journal={Archiv der Pharmazie},
  year={1992},
  volume={325}
}
A preliminary pharmacological study of a thiophene analogue 1b of the analgesic and antipyretic agent Ethenzamide and of a closely related compound 1a showed that a great similarity exists among Ethenzamide and the thiophenic compounds for analgesic, antipyretic, ulcerogenic, hypothermic, and sedative effects. However, the acute toxicity in mice for the thiophenic compounds is notably higher than that of Ethenzamide. 
16 Citations
Design, synthesis and biological evaluation of novel thiophene and theinopyrimidine derivatives as anticancer agents
  • 5
Solubility Determination and Thermodynamic Correlation of 2-Ethoxybenzamide in 12 Pure Solvents from 288.15 to 328.15 K
  • Kuo Wang, Zeren Shang, Jiayin Zhang, Yumin Liu, Jianhua Han, Weiwei Tang
  • Chemistry
  • 2021
Crystal structure of 2-pentyloxybenzamide
  • PDF
...
1
2
...

References

SHOWING 1-10 OF 12 REFERENCES
THE ANALGESIC AND ANTIPYRETIC PROPERTIES OF SOME DERIVATIVES OF SALICYLAMIDE
  • 36
Analgesic potency and acute toxicity of substituted anilides and benzamides.
  • 24
Some aspects of the pharmacology of ibufenac, a non‐steroidal anti‐inflammatory agent
  • 90
A Method for Evaluating both Non-Narcotic and Narcotic Analgesics
  • E. Siegmund, R. Cadmus, G. Lu
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1957
  • 454
Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs
  • C. Winter, E. Risley, G. Nuss
  • Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
  • 5,171
...
1
2
...