Synthesis and Preclinical Evaluation of [18F]FCHC for Neuroimaging of Fatty Acid Amide Hydrolase

@article{Shoup2014SynthesisAP,
  title={Synthesis and Preclinical Evaluation of [18F]FCHC for Neuroimaging of Fatty Acid Amide Hydrolase},
  author={Timothy M. Shoup and Ali Akbarpour Bonab and Alan A. Wilson and Neil Vasdev},
  journal={Molecular Imaging and Biology},
  year={2014},
  volume={17},
  pages={257-263}
}
Fatty acid amide hydrolase (FAAH), a catabolic enzyme which regulates lipid transmitters in the endocannabinoid system, is an avidly sought therapeutic and positron emission tomography (PET) imaging target for studies involving addiction and neurological disorders. We report the synthesis of a new fluorine-18-labeled FAAH inhibitor, trans-3-(4, 5-dihydrooxazol-2-yl)phenyl-4-[18F]fluorocyclohexylcarbamate ([18F]FCHC), and its evaluation in rat brain. The synthesis of [18F]FCHC was conducted via… CONTINUE READING
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