Synthesis and Potential Coanthracyclinic Activity of Substituted 3‐(5‐Imidazo[2,1‐b]thiazolylmethylene)‐2‐indolinones.

@article{Andreani1998SynthesisAP,
  title={Synthesis and Potential Coanthracyclinic Activity of Substituted 3‐(5‐Imidazo[2,1‐b]thiazolylmethylene)‐2‐indolinones.},
  author={Aldo Andreani and Alessandra Locatelli and Alberto Leoni and Mirella Rambaldi and Rita Morigi and Rosaria Bossa and Michele Chiericozzi and A Fraccari and Iraklis Galatulas},
  journal={ChemInform},
  year={1998},
  volume={29}
}
1 Citations

Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.

TLDR
The most potent compounds strongly and selectively inhibited the phosphorylation of the oncoprotein kinase Akt in cancer cells and caused the cells to arrest in the G2/M phase of the cell cycle, as would be expected for inhibitors of tubulin assembly.