Corpus ID: 212512202

Synthesis and Pharmacological Investigations of Azetidinones Involving 3-Mercapto-4-amino-5-naphtho[2,1- b]furan-1,2,4-triazole

  title={Synthesis and Pharmacological Investigations of Azetidinones Involving 3-Mercapto-4-amino-5-naphtho[2,1- b]furan-1,2,4-triazole},
  author={M Kumaraswamy and VP. Vaidya and Cheemalamarri Chandrasekhar and DA. Prathima Mathias and H. G. Shivakumar and K Mahadevan},
  • M Kumaraswamy, VP. Vaidya, +3 authors K Mahadevan
  • Published 2013
  • The reaction of naphtho[2,1-b]furan-2-carbohydrazide 1 with carbon disulphide and excess of hydrazine hydrate in ethanol produced 4-amino-5-naphtho[2,1-b]furan-2-yl-4H-1,2,4-triazole-3-thiol 2. The thiol 2 on treatment with aromatic aldehydes yielded 4-{[(4-aryl)methylene]amino}-5(naphtho[2,1-b]furan-2-yl)-4H-1,2,4-triazole-3-thiols 3a-f. The title compounds, chloro-1-(3mercapto-5-naphtho[2,1-b]furan-2-yl-1,2,4-triazole-4-yl)-2-(aryl)-azetidin-4-ones 4a-f were obtained by reacting compounds 3a… CONTINUE READING

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    Publications referenced by this paper.

    Anti-inflammatory and antinociceptive evaluation of newly synthesized 4-(substituted ethanoyl) amino-3-mercapto-5-(4methoxy) phenyl-1,2,4-triazoles

    • Neeraj Upmanyu, Jeetendra Kumar Gupta, Kamal Shah, Pradeep Mishra
    • J Pharm Bioallied Sci
    • 2011

    Synthesis and pharmacological activities of some new 3-Substituted-4-Amino5 Mercapto-1,2,4-triazoles

    • RD Shobha, U Laddi, SB Rajani, PA Patil, S. Bennur
    • Indian J Pharm Sci
    • 2011

    Synthesis, antimicrobial and insecticidal activity of some 4H1,2,4-triazole derivatives

    • Nidhi Goutam, OP Chourasia
    • Indian J Chem
    • 2010

    Novel approach towards the synthesis of 2-(1naphtho[2,1-b]furan-2-ylcarbonyl)3,5-disubstituted-2,3-dihydro-1Hpyrazoles: As a new class of antimicrobial and pharmacological agents

    • MN Kumaraswamy, DA Prathima Mathias, +3 authors VP. Vaidya
    • Indian J Pharma Sci
    • 2008

    Synthesis and Biological Activity of NSubstituted-3-chloro-2azetidinones

    • AA Chavan, NR Pai
    • Molecules
    • 2007

    Synthesis and pharmacological evaluation of 2mercapto-4-substituted-naphtho [2,1-b]furo[3,2-d]pyrimidines

    • MN Kumaraswamy, DA Prathima Mathias, C Chandrashekhar, VP. Vaidya
    • Indian J Pharma Sci
    • 2006