Corpus ID: 212512202

Synthesis and Pharmacological Investigations of Azetidinones Involving 3-Mercapto-4-amino-5-naphtho[2,1- b]furan-1,2,4-triazole

@inproceedings{Kumaraswamy2013SynthesisAP,
  title={Synthesis and Pharmacological Investigations of Azetidinones Involving 3-Mercapto-4-amino-5-naphtho[2,1- b]furan-1,2,4-triazole},
  author={M Kumaraswamy and VP. Vaidya and Cheemalamarri Chandrasekhar and DA. Prathima Mathias and H. G. Shivakumar and K Mahadevan},
  year={2013}
}
  • M Kumaraswamy, VP. Vaidya, +3 authors K Mahadevan
  • Published 2013
  • The reaction of naphtho[2,1-b]furan-2-carbohydrazide 1 with carbon disulphide and excess of hydrazine hydrate in ethanol produced 4-amino-5-naphtho[2,1-b]furan-2-yl-4H-1,2,4-triazole-3-thiol 2. The thiol 2 on treatment with aromatic aldehydes yielded 4-{[(4-aryl)methylene]amino}-5(naphtho[2,1-b]furan-2-yl)-4H-1,2,4-triazole-3-thiols 3a-f. The title compounds, chloro-1-(3mercapto-5-naphtho[2,1-b]furan-2-yl-1,2,4-triazole-4-yl)-2-(aryl)-azetidin-4-ones 4a-f were obtained by reacting compounds 3a… CONTINUE READING

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