Synthesis and Pharmacological Evaluation of Novel Selenoethers Glycerol Derivatives for the Treatment of Pain and Inflammation: Involvement of Nitrergic and Glutamatergic Systems

@article{Perin2018SynthesisAP,
  title={Synthesis and Pharmacological Evaluation of Novel Selenoethers Glycerol Derivatives for the Treatment of Pain and Inflammation: Involvement of Nitrergic and Glutamatergic Systems},
  author={Gelson Perin and Helen A. Goulart and Liane K. Soares and Thiago J. Peglow and Ricardo F. Schumacher and Mikaela P. Pinz and Ang{\'e}lica S. Reis and Cristiane Luchese and Ethel A. Wilhelm},
  journal={Applied Biochemistry and Biotechnology},
  year={2018},
  volume={187},
  pages={1398-1423}
}
AbstractIn the present study, the synthesis of new selenoethers from nucleophilic substitution reaction between organyl halides and nucleophilic species of selenium generated in situ was demonstrated. After, this method was applied for the synthesis of pyridylselenides glycerol derivatives 9b and 9c and the antinociceptive and anti-inflammatory effects, as well as, acute toxicity were evaluated. In the formalin test, the compound 9b caused a reduction in licking time in both phases. Compounds… CONTINUE READING

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