Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles.

@article{Minhas2006SynthesisAG,
  title={Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles.},
  author={Gurpreet Singh Minhas and Daniel S. Pilch and John E. Kerrigan and Edmond J Lavoie and Joseph E. Rice},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 15},
  pages={3891-5}
}
The synthesis of 24-membered macrocycles containing four, six, and seven oxazole moieties is described. Selected compounds were evaluated for their ability to specifically bind and stabilize G-quadruplex DNA and for cytotoxic activity. An unexpected oxidative cleavage reaction afforded a macrocyclic imide that was also evaluated for G-quadruplex stabilizing and cytotoxic activity. 

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…