Synthesis and Evaluation of Novel α-Aminoamides Containing an Indole Moiety for the Treatment of Neuropathic Pain.

@article{Li2016SynthesisAE,
  title={Synthesis and Evaluation of Novel α-Aminoamides Containing an Indole Moiety for the Treatment of Neuropathic Pain.},
  author={Haotian Li and Shiyong Fan and Jingchao Cheng and Ping Zhang and Bo-hua Zhong and Weiguo Shi},
  journal={Molecules},
  year={2016},
  volume={21 7}
}
The α-aminoamide family of sodium ion channel blockers have exhibited analgesic effects on neuropathic pain. Here, a series of novel α-aminoamides containing an indole ring were designed and synthesized. These compounds were evaluated in mice using a formalin test and they exhibited significant anti-allodynia activities. However, the analgesic mechanism of… CONTINUE READING