Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation

@article{Magolan2012SynthesisAE,
  title={Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation},
  author={J. Magolan and Nathan B P Adams and H. Onozuka and N. Hungerford and H. Esumi and M. J. Coster},
  journal={ChemMedChem},
  year={2012},
  volume={7}
}
Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient-deprived, resistant cancer cells. Through structure-activity relationship studies, three analogues were identified as lead compounds for the develpoment of molecular probes for the investigation of the mode of action and biological targets of the antiausterity compounds. 
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References

SHOWING 1-10 OF 47 REFERENCES
Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.
  • 64
Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative.
  • 84
Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar.
  • 34
Highly enantioselective synthesis of angelmarin.
  • 21
  • PDF
Synthesis and activity of a folate peptide camptothecin prodrug.
  • 119
Novel anticancer agents, kayeassamins C-I from the flower of Kayea assamica of Myanmar.
  • 38
...
1
2
3
4
5
...