Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases.

@article{Amici2017SynthesisAD,
  title={Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases.},
  author={Adolfo Amici and Ambra A Grolla and Erika Del Grosso and Roberta Bellini and Michele Bianchi and Cristina Travelli and Silvia Garavaglia and Leonardo Sorci and Nadia Raffaelli and Silverio Ruggieri and Armando A Genazzani and Giuseppe Orsomando},
  journal={Cell chemical biology},
  year={2017},
  volume={24 5},
  pages={553-564.e4}
}
Adenosine 5'-tetraphosphate (Ap4) is a ubiquitous metabolite involved in cell signaling in mammals. Its full physiological significance remains unknown. Here we show that two enzymes committed to NAD biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPT), can both catalyze the synthesis and degradation of Ap4 through their facultative ATPase activity. We propose a mechanism for this unforeseen additional reaction, and demonstrate its… CONTINUE READING
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