Synthesis and Cytotoxicity Evaluation of Some 8‐Hydroxyquinoline Derivatives

@article{Shen1999SynthesisAC,
  title={Synthesis and Cytotoxicity Evaluation of Some 8‐Hydroxyquinoline Derivatives},
  author={Ai Yu Shen and S. -N. Wu and C T Chiu},
  journal={Journal of Pharmacy and Pharmacology},
  year={1999},
  volume={51}
}
Interest in Mannich bases of 8‐hydroxyquinoline stems from reports of their high potency against human cancer cells. In the search for potential anticancer drug candidates, Mannich bases of 8‐hydroxyquinoline (7‐pyrrolidinomethyl‐8‐hydroxyquinoline, 7‐morpholinomethyl‐8‐hydroxyquinoline, 7‐piperidinomethyl‐8‐hydroxyquinoline and 7‐diethylamino‐methyl‐8‐hydroxyquinoline) were synthesised by reaction with various secondary amines and formaldehyde. They were prepared as hydrochlorides. 
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