Synthesis and Cytotoxicity Evaluation of Some 8‐Hydroxyquinoline Derivatives

  title={Synthesis and Cytotoxicity Evaluation of Some 8‐Hydroxyquinoline Derivatives},
  author={Ai Yu Shen and S. -N. Wu and C T Chiu},
  journal={Journal of Pharmacy and Pharmacology},
Interest in Mannich bases of 8‐hydroxyquinoline stems from reports of their high potency against human cancer cells. In the search for potential anticancer drug candidates, Mannich bases of 8‐hydroxyquinoline (7‐pyrrolidinomethyl‐8‐hydroxyquinoline, 7‐morpholinomethyl‐8‐hydroxyquinoline, 7‐piperidinomethyl‐8‐hydroxyquinoline and 7‐diethylamino‐methyl‐8‐hydroxyquinoline) were synthesised by reaction with various secondary amines and formaldehyde. They were prepared as hydrochlorides. 
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New heterocycles from 8-hydroxyquinoline via dipolar 1,3-cycloadditions: Synthesis & biological evaluation
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Studies on the structures, cytotoxicity and apoptosis mechanism of 8-hydroxylquinoline rhodium(III) complexes in T-24 cells
Two rhodium(III) complexes (Rh(OQ)3 (1) and Rh(BrQ)2(CH3OH)Cl (2), HOQ = 8-hydroxyquinoline, HBrQ = 5-bromo-8-hydroxyquinoline) of 8-hydroxylquinoline were synthesized and characterized. By MTTExpand
Synthesis, Structure Characterization and Antitumor Activity Study of a New Iron(III) Complex of 5-Nitro-8-hydroxylquinoline (HNOQ).
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  • European Journal of Medicinal Chemistry
  • 2015
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Quinoline-derivative coordination compounds as potential applications to antibacterial and antineoplasic drugs.
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Direct radioiodination of metabolic 8-hydroxy-quinolyl-glucuronide, as a potential anti-cancer drug
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Direct radioiodination of metabolic 8-hydroxy-quinolyl-glucuronide, as a potential anti-cancer drug.
  • T. Unak, P. Unak
  • Medicine
  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • 1996
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Effects of 1‐pyrrolidinylmethyl‐2‐naphthol on contractile force and ionic current in cardiac and vascular smooth myocytes
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