Synthesis and Cytotoxic Evaluation of 1,2,3-Trisubstituted 2-(2-Oxoalkyl)-2,3-dihydrobenzimidazoles

A new series of 1,2,3-trisubstituted 2-(2-oxoalkyl)-2,3-dihydrobezimidazoles have been synthesized and evaluated for their cytotoxic activity using one normal (FL) and two cancer (RD and A2058) cell lines. Among the nine compounds tested, 5h showed the best selective antiproliferative properties in vitro, being especially active against the human metastatic… CONTINUE READING