Synthesis and Cytotoxic Evaluation of Novel 3-Substituted Derivatives of 2-Indolinone

@inproceedings{Mokhtari2012SynthesisAC,
  title={Synthesis and Cytotoxic Evaluation of Novel 3-Substituted Derivatives of 2-Indolinone },
  author={Shaya Mokhtari and Mahmoud Mosaddegh and Maryam Hamzeloo Moghadam and Zohreh Soleymani and Saeideh Ghafari and Farzad Kobarfard},
  booktitle={Iranian journal of pharmaceutical research : IJPR},
  year={2012}
}
The assessment of the degree or rate of cellular proliferation and cell viability is critical for the assessment of the effects of drugs on both normal and malignant cell populations. In the present study, a few novel 3-substituted derivatives of 2-indolinones were synthesized by condensation of substituted oxindole or isatin derivatives with appropriate aldehydes or primary aromatic amines respectively. The synthesized compounds were screened for their cytotoxicity against HT-29 (human colon… CONTINUE READING

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