Synthesis and Characterization of a "Turn-On" photoCORM for Trackable CO Delivery to Biological Targets.

@article{Carrington2014SynthesisAC,
  title={Synthesis and Characterization of a "Turn-On" photoCORM for Trackable CO Delivery to Biological Targets.},
  author={Samantha J Carrington and Indranil Chakraborty and Jenna M. L. Bernard and Pradip K Mascharak},
  journal={ACS medicinal chemistry letters},
  year={2014},
  volume={5 12},
  pages={1324-8}
}
A designed photoactive CO releasing molecule (photoCORM), namely, fac-[MnBr(CO)3(pbt)] (1, pbt = 2-(2-pyridyl)benzothiazole), promotes CO-induced death of MDA-MB-231 human breast cancer cells upon illumination with broadband visible light. The CO release from this photoCORM can be tracked by rise in fluorescence within the cellular matrix due to deligation of the pbt ligand. The results of this study suggest the potential of 1 in eradication of cancer cells through CO delivery. 
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