Synthesis and Characterization of Tissue Plasminogen Activator—Functionalized Superparamagnetic Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution

@inproceedings{Heid2017SynthesisAC,
  title={Synthesis and Characterization of Tissue Plasminogen Activator—Functionalized Superparamagnetic Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution},
  author={Susanne Heid and Harald Unterweger and Rainer Tietze and Ralf Philipp Friedrich and Bianca Weigel and Iwona Cicha and Dietmar Eberbeck and Aldo R Boccaccini and Christoph Alexiou and Stefan Lyer},
  booktitle={International journal of molecular sciences},
  year={2017}
}
Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted great attention in many biomedical fields and are used in preclinical/experimental drug delivery, hyperthermia and medical imaging. In this study, biocompatible magnetite drug carriers, stabilized by a dextran shell, were developed to carry tissue plasminogen activator (tPA) for targeted thrombolysis under an external magnetic field. Different concentrations of active tPA were immobilized on carboxylated nanoparticles through… CONTINUE READING